My favorite comic may be Penuts and my favorite cartoonist may be the great Charles Schulz....okay, here's a chart:
3) A tie between Pearls Before Swine, Foxtrot, and Calvin And Hobbes
But my favorite LINE from a comic is from a Pearls Before Swine comic. It's Larry (the father crocodile)'s line in panel three:
There you go! All credit goes to Stephan Pastis.